HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 1-Benzylsulfanyl-4-methanesulfonyl-2-nitro-benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Benzyl mercaptan | HCID 7509 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-Chloro-3-nitrophenyl methyl sulfone | HCID 66796 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Benzylsulfanyl-4-methanesulfonyl-2-nitro-benzene | HCID 9283420 | 92.1% |
Reaction Steps
In a similar fashion using route 38 general procedure 92, 1-chloro-4-methanesulfonyl-2-nitrobenzene (750 mg, 3.19 mmol), benzylmercaptan (450 ml, 3.82 mmol), Na2CO3 (439 mg, 4.14 mmol) and EtOH:water (25 ml: 18 ml) at 90° C. for 4 h gave the title compound (950 mg, 92%) which was used in the next step without further purification. The structure was confirmed by 1H NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-69863f97c8e34f98b3d23e334fa1e755 |
| Source note | uspto-grants-2015_08 |