HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl mercaptan → HCID 68183412, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl mercaptan | HCID 7509 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Bromo-5-(trifluoromethyl)pyridine | HCID 11127991 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 68183412 | HCID 68183412 | 25.7% |
Reaction Steps
In a similar fashion using route 38 general procedure 92, 3-bromo-5-(trifluoromethyl)pyridine (400 mg, 1.76 mmol), K2CO3 (366 mg, 2.65 mmol), benzylmercaptan (330 mg, 2.65 mmol) and DMSO (3.2 ml) at 150° C. for 4 h in sealed tube gave the title compound (122 mg, 25%) after purification by column chromatography with n-hexane/EtOAc (99:1) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-bcf43981183b466cb50f7bd5e0a3c251 |
| Source note | uspto-grants-2015_08 |