HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Fluoro-5-methyl-2-nitro-benzenesulfonic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Sulfite | HCID 24437 | — |
| Reactant | 1,4-Difluoro-2-methyl-5-nitrobenzene | HCID 230658 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Fluoro-5-methyl-2-nitro-benzenesulfonic acid | HCID 86669766 | 73.6% |
Reaction Steps
In a similar fashion using route 39 general procedure 95, 1,4-difluoro-2-methyl-5-nitrobenzene (1.2 g, 6.93 mmol) in EtOH (10 ml) and Na2SO3 (1.98 g, 15.7 mmol) in EtOH:water (40 ml:25 ml) at 70° C. for 16 h gave the title compound (1.2 g, 73%) which was used in the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-51c1a3014a69401fa6314e5f4b249712 |
| Source note | uspto-grants-2015_08 |