HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Fluoro-6-nitrobenzenesulfonic acid | HCID 12904370 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride | HCID 12904368 | — |
Reaction Steps
In a similar fashion using route 39 general procedure 96, 5-fluoro-2-nitro-benzenesulfonic acid 450 (0.6 g, 2.71 mmol), SOCl2 (3.1 ml) and DMF (0.06 ml) at 90° C. for 3 h gave the title compound (3.4 g) which was used in the next step without further purification. The structure was confirmed by 1H NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-c32e5e7874b341e3886b6cef63e5ae9f |
| Source note | uspto-grants-2015_08 |