HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitric Acid → 4-Chloro-8-nitroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 4-Chloroquinoline | HCID 69140 | — |
| Product | 4-Chloro-8-nitroquinoline | HCID 610440 | 36% |
Reaction Steps
In a similar fashion using route 11 general procedure 57, 4-chloroquinoline 462 (5.0 g, 30.7 mmol), fuming HNO3 (8.3 ml) and concentrated H2SO4 (16.6 ml) to give the title compound (2.3 g, 36%) which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-f3262b3591a54fe58195fd968cc87ed5 |
| Source note | uspto-grants-2015_08 |