HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Chloroquinolin-8-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 4-Chloro-8-nitroquinoline | HCID 610440 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Chloroquinolin-8-amine | HCID 12604274 | 81.5% |
Reaction Steps
In a similar fashion using route 2 general procedure 4, 4-chloro-8-nitroquinoline 463 (3.3 g, 15.8 mmol), SnCl2 (15 g, 79.1 mmol), conc. HCl (cat.) and MeOH (100 ml) to give the title compound (2.3 g, 36%) which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-b21cad1fcc73415485322d2904f78986 |
| Source note | uspto-grants-2015_08 |