HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)quinoline → 8-Nitro-4-trifluoromethyl-quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)quinoline | HCID 2777807 | — |
| Reactant | Sulfuric acid, mixt. with nitric acid | HCID 71777668 | — |
| Product | 8-Nitro-4-trifluoromethyl-quinoline | HCID 68183206 | 29% |
Reaction Steps
In a similar fashion using route 11 general procedure 57, 4-trifluoromethyl-quinoline 467 (200 mg, 1.01 mmol) and H2SO4:HNO3 (2:1) gave the title compound (70 mg, 29%) which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-46f643e9243a4e88bc7e6d10fde5c9d0 |
| Source note | uspto-grants-2015_08 |