HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 8-Quinolinamine, 4-(trifluoromethyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 8-Nitro-4-trifluoromethyl-quinoline | HCID 68183206 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 8-Quinolinamine, 4-(trifluoromethyl)- | HCID 68183204 | 89% |
Reaction Steps
In a similar fashion using route 2 general procedure 4, 8-nitro-4-trifluoromethyl-quinoline 468 (900 mg, 4.13 mmol), SnCl2 (3.12 g, 16.5 mmol), 6N HCl (2 drops) and EtOH (20 ml) at 85° C. for 3 h gave the title compound (700 mg, 89%) which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-3bc4b273e9c84307acfff241f4a43ef5 |
| Source note | uspto-grants-2015_08 |