HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 8-Aminoquinoline-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 8-Nitroquinoline-5-carbonitrile | HCID 68183420 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 8-Aminoquinoline-5-carbonitrile | HCID 68183361 | 86.9% |
Reaction Steps
In a similar fashion using route 19 general procedure 29, 8-nitroquinoline-5-carbonitrile 471 (350 mg, 1.7 mmol), SnCl2 (1.3 g, 7.0 mmol), 6N HCl (4 drops) and EtOH (10 ml) gave the title compound (250 mg, 86%) which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-a15db445fa89492ebebd978bc81edd05 |
| Source note | uspto-grants-2015_08 |