反应详情

1N NaOH (9 ml) was added to a solution of N′-(8-aminoquinazolin-4-yl)-4-methylbenzene-1-sulfonohydrazide 479 (300 mg, 9.1 mmol) in EtOH (20 ml) and the mixture was heated under reflux for 3 h. After cooling, the mixture was concentrated in vacuo. The residue was diluted with water (10 ml) and the aqueous phase was extracted with EtOAc. The organic phase was washed with brine, dried (Na2SO4), and concentrated in vacuo to give title compound (140 mg, 76%) which was used in the next step without further purification. The structure was confirmed by 1H NMR.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 3 h
3. temperatureAfter cooling
4. concentrationthe mixture was concentrated in vacuo
5. additionThe residue was diluted with water (10 ml)
6. extractionthe aqueous phase was extracted with EtOAc
7. washThe organic phase was washed with brine
8. dry with materialdried (Na2SO4)
9. concentrationconcentrated in vacuo