4-Methoxybenzylamine → (4-Methoxy-benzyl)-[1,5]naphthyridin-4-yl-amine

Participants

Reaction Conditions

Reaction Steps

p-Methoxybenzylamine (1.45 g, 10.6 mmol) was added to a solution of 4-chloro-[1,5]naphthyridine 484 (0.35 g, 2.13 mmol) in n-BuOH (9 ml) and the mixture was heated at 150° C. for 18 h. The solvent was removed in vacuo. The crude residue was purified by column chromatography with n-hexane/EtOAc (80:20) as the eluent to give the title compound (0.5 g, 89%).

Provenance & Evidence