関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | (4-Methoxy-benzyl)-[1,5]naphthyridin-4-yl-amine | HCID 68183180 | — |
| 生成物 | Ammonia | HCID 222 | — |
| 生成物 | 1,5-Naphthyridin-4-amine | HCID 589354 | 183.2% |
反応手順
48% HBr (13 ml) was added to (4-methoxy-benzyl)-[1,5]naphthyridin-4-yl-amine 485 (0.5 g, 1.88 mmol) and the mixture was heated at 80° C. for 2 h. After cooling, the mixture was neutralized with sat. NaHCO3 solution and the aqueous phase was extracted with EtOAc (80 ml). The organic phase was washed with water, dried (Na2SO4) and concentrated in vacuo. The crude residue was purified by column chromatography with DCM/MeOH/Aq. NH3 (97:2:1) as the eluent to give the title compound (0.25 g, 90%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09102688B2 |
|---|
| 出典データセット | uspto-grants-2015_08 |
|---|
| ORD ID | ord-1c2a075070054a5a80d59412cb89a2be |
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| 出典メモ | uspto-grants-2015_08 |
|---|
