HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → N-(4-Dimethylamino-quinolin-8-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | N-(4-Chloro-quinolin-8-yl)-benzenesulfonamide | HCID 68183402 | — |
| Product | N-(4-Dimethylamino-quinolin-8-yl)-benzenesulfonamide | HCID 68183396 | 23.2% |
Reaction Steps
In a similar fashion using route 48 general procedure 114, N-(4-chloro-quinolin-8-yl)-benzenesulfonamide 224 (80 mg, 0.250 mmol) and dimethyl amine (2M in THF; 1.25 ml, 2.50 mmol) gave the title compound (19 mg, 23%) after purification by column chromatography with chloroform/MeOH (1 drop NH3) (98:2) as the eluent followed by recrystallisation from MeOH/DCM.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-f8d9f6f9a6b846cdbed2686e0f980fe3 |
| Source note | uspto-grants-2015_08 |