Methylamine → N-(4-Methylamino-quinolin-8-yl)-benzenesulfonamide

Participants

Reaction Steps

In a similar fashion using route 48 general procedure 114, N-(4-chloro-quinolin-8-yl)-benzenesulfonamide 224 (80 mg, 0.25 mmol), methyl amine (2M in THF; 1.23 ml, 2.50 mmol) at 100° C. for 48 h gave the title compound (10 mg, 13%) after purification by column chromatography with chloroform/MeOH (1 drop NH3) (98:2) as the eluent followed by recrystallisation from MeOH/DCM.

Provenance & Evidence