HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 68183227, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-Boc-3-pyrrolidinol | HCID 4416939 | — |
| Reactant | 12-Chloro-9-fluoro-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide | HCID 68183182 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 68183227 | HCID 68183227 | 14% |
Reaction Steps
In a similar fashion using route 51 general procedure 119, 12-chloro-9-fluoro-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide 503 (0.2 g, 0.6 mmol), 1-boc-3-pyrrolidinol (0.45 g, 2.3 mmol), NaH (60% in mineral oil; 57 mg, 2.3 mmol) and NMP (2 ml) gave the title compound (33 mg, 14%) after purification by preparative HPLC (acidic conditions 2). Boc deprotection occurred in situ during heating.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-e59a37493a3649a79affcb58196a3cc0 |
| Source note | uspto-grants-2015_08 |