HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Dimethylamino)ethanol → HCID 68183383, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Dimethylamino)ethanol | HCID 7902 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 12-Chloro-9-fluoro-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide | HCID 68183182 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 68183383 | HCID 68183383 | 13% |
Reaction Steps
In a similar fashion using route 51 general procedure 119, 12-chloro-9-fluoro-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide 503 (200 mg, 0.59 mmol), N,N-dimethyl ethanolamine (210 mg, 2.3 mmol), NaH (60% in mineral oil; 71 mg, 1.79 mmol) and NMP (2 ml) gave the title compound (30 mg, 13%) after purification by column chromatography with DCM/MeOH (98:2) elution.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-839867b391d7408eb448eeb354baab50 |
| Source note | uspto-grants-2015_08 |