Ammonia → HCID 68190285, compound

Participants

Reaction Steps

A solution of 6,6-dioxo-5,6-dihydro-6λ*6*-thia-4,5-diaza-chrysene-9-carboxylic acid methyl ester 307 (50 mg, 0.15 mmol) in 7M NH3 in MeOH (5 ml) was heated at 90 C in sealed tube for 36 h. After cooling, the mixture was concentrated in vacuo. The crude residue was purified by column chromatography with DCM/MeOH (95:5) as the eluent to give the title compound (8 mg, 17%).

Provenance & Evidence