HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → 12-bromo-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 5H-quinolino[8,7-c][1,2]benzothiazine 6,6-dioxide | HCID 659101 | — |
| Solvent | Dioxane chloroform | HCID 66618785 | — |
| Product | 12-bromo-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide | HCID 16759944 | 64.6% |
Reaction Steps
Bromine (170 μl, 3.30 mmol) was added dropwise to a solution of 5H-6-thia-4,5-diaza-chrysene 6,6-dioxide 184 (467 mg, 1.65 mmol) in 1,4-dioxane/chloroform (1:1, 124 ml) at 0° C. After 2 h, chloroform (30 ml) was added and the resulting precipitate was collected by filtration. The solid was triturated from MeOH to give the title compound (385 mg, 64%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-daaaa82d67ee45059b47badcf9e0cdcf |
| Source note | uspto-grants-2015_08 |