HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 12-Piperidin-1-yl-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl | HCID 11155794 | — |
| Reactant | 12-bromo-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide | HCID 16759944 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 12-Piperidin-1-yl-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide | HCID 68183459 | 19% |
Reaction Steps
In a similar fashion using route 58 general procedure 126, piperidine (41 μl, 0.42 mmol), Pd2(dba)3 (3 mg, 3 μmol), X-Phos (7 mg, 14 μmol), NaOtBu (67 mg, 0.69 mmol), 12-bromo-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide 545 (100 mg, 0.28 mmol) and toluene (2 ml) gave the title compound (19 mg, 19%) after purification by preparative HPLC (acidic conditions 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-1a79757f6c7a40adae8cf25f1df45c06 |
| Source note | uspto-grants-2015_08 |