Pyrrolidine → 12-Pyrrolidin-1-yl-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide

Participants

Reaction Conditions

Reaction Steps

Toluene was de-gassed for 15 min. Toluene (2 ml) and pyrrolidine (30 μl, 0.42 mmol) were added to a mixture of Pd2(dba)3 (25 mg, 28 μmol), X-Phos (66 mg, 0.14 mmol), NaOtBu (67 mg, 0.69 mmol), 12-bromo-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide 545 (100 mg, 0.28 mmol), under nitrogen and the mixture was heated at 90° C. for 18 h. After cooling, the mixture was diluted with MeOH (3 ml), filtered and concentrated in vacuo. The residue was purified by preparative HPLC (acidic conditions 1) to give the title compound (33 mg, 34%).

Provenance & Evidence