HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 6,6-Dioxo-5,6-dihydro-6lambda*6*-thia-4,5-diaza-chrysene-12-carboxylic acid (2dimethylamino-ethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | N,N-Dimethylethylenediamine | HCID 66053 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 12-bromo-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide | HCID 16759944 | — |
| Product | 6,6-Dioxo-5,6-dihydro-6lambda*6*-thia-4,5-diaza-chrysene-12-carboxylic acid (2dimethylamino-ethyl)-amide | HCID 68190798 | 39% |
Reaction Steps
In a similar fashion using route 58 general procedure 128, N*1*,N*1*-dimethyl-ethane-1,2-diamine (73 mg, 0.83 mmol), 12-bromo-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide 545 (100 mg, 0.28 mmol), Hermann's palladacycle (13 mg, 14 μmol, Mo(CO)6 (73 mg, 0.28 mmol), DBU (126 mg, 0.83 mmol) and THF (2 ml) gave the title compound (43 mg, 39%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-eec276cfc4df40a59e48d32d2419ac39 |
| Source note | uspto-grants-2015_08 |