HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitrobenzenesulfonyl chloride → N-(5-Benzyloxy-quinolin-8-yl)-2-nitro-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitrobenzenesulfonyl chloride | HCID 15540 | — |
| Reactant | 5-(Benzyloxy)quinolin-8-amine | HCID 43449587 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-(5-Benzyloxy-quinolin-8-yl)-2-nitro-benzenesulfonamide | HCID 68183366 | 89% |
Reaction Steps
In a similar fashion using route 18 general procedure 26, 5-benzyloxy-quinolin-8-ylamine 565 (336 mg, 1.34 mmol), 2-nitrobenzenesulfonyl chloride (357 mg, 1.61 mmol), and pyridine (3 ml) gave the title compound (519 mg, 89%) which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-87cfd87856e846d0ae97d2c3d2c0a3d5 |
| Source note | uspto-grants-2015_08 |