HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → N-(5-Benzyloxy-quinolin-8-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Tert-Butyl nitrite | HCID 10906 | — |
| Reactant | 2-Amino-N-(5-benzyloxy-quinolin-8-yl)-benzenesulfonamide | HCID 68183505 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(5-Benzyloxy-quinolin-8-yl)-benzenesulfonamide | HCID 68183148 | 5.5% |
Reaction Steps
In a similar fashion using route 20 general procedure 36, 2-amino-N-(5-benzyloxy-quinolin-8-yl)-benzenesulfonamide 567 (417 mg, 1.03 mmol), t-butyl nitrite (209 μl, 1.75 mmol), AcOH (4 ml) and THF (10 ml) gave the title compound (22 mg, 5%) after purification by preparative HPLC (acidic conditions 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-5f2a3fd92ce442c89a2cdcb17f9dbe96 |
| Source note | uspto-grants-2015_08 |