HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitrobenzenesulfonyl chloride → N-(5-Morpholin-4-yl-quinolin-8-yl)-2-nitro-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitrobenzenesulfonyl chloride | HCID 15540 | — |
| Reactant | 8-Amino-5-morpholinoquinoline | HCID 14501162 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-(5-Morpholin-4-yl-quinolin-8-yl)-2-nitro-benzenesulfonamide | HCID 68182942 | 78% |
Reaction Steps
In a similar fashion using route 18 general procedure 26, 5-morpholin-4-yl-quinolin-8-ylamine 581 (154 mg, 0.67 mmol), 2-nitrobenzenesulfonyl chloride (148.86 mg, 0.67 mmol), and pyridine (1 ml) gave the title compound (216 mg, 78%) after purification by column chromatography with DCM/MeOH (100%-98:2 gradient) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-3932990c64544007b26daa0358ac6e13 |
| Source note | uspto-grants-2015_08 |