HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → N-(5-Morpholin-4-yl-quinolin-8-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Tert-Butyl nitrite | HCID 10906 | — |
| Reactant | 2-Amino-N-(5-morpholin-4-yl-quinolin-8-yl)-benzenesulfonamide | HCID 68183436 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(5-Morpholin-4-yl-quinolin-8-yl)-benzenesulfonamide | HCID 68183078 | 7% |
Reaction Steps
In a similar fashion using route 20 general procedure 36, 2-amino-N-(5-morpholin-4-yl-quinolin-8-yl)-benzenesulfonamide 583 (150 mg, 0.39 mmol), tert-butyl nitrite (79.53 μl, 0.66 mmol), AcOH (1.5 ml) and THF (3 ml) gave the title compound (10 mg, 7%) after purification by preparative HPLC (acidic conditions 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-85b1e7fd8c6a421ead512f965adbc488 |
| Source note | uspto-grants-2015_08 |