反应详情

温度

80 °C

NaOMe (570 mg, 10.5 mmol) was added to a solution of 5-chloro-8-nitroquinoline 27 (550 mg, 2.64 mmol) in MeOH (15 ml) and the mixture was heated at 80° C. for 2 h. The solvent was removed in vacuo and the residue was diluted with water and the aqueous phase was extracted with DCM. The organic phase was washed with brine and concentrated in vacuo to give the title compound (500 mg, 93%) which was used in the next step without further purification.

1. customThe solvent was removed in vacuo
2. additionthe residue was diluted with water
3. extractionthe aqueous phase was extracted with DCM
4. washThe organic phase was washed with brine
5. concentrationconcentrated in vacuo