HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Pyridine → N-(5-Methoxy-quinolin-8-yl)-2-nitro-4-trifluoromethyl-benzenesulfonamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Pyridine | HCID 1049 | — |
| Edukt | 5-Methoxyquinolin-8-amine | HCID 777110 | — |
| Edukt | 2-Nitro-4-(trifluoromethyl)benzene-1-sulfonyl chloride | HCID 2775780 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | N-(5-Methoxy-quinolin-8-yl)-2-nitro-4-trifluoromethyl-benzenesulfonamide | HCID 68183320 | 73,1% |
Reaktionsschritte
In a similar fashion using route 18 general procedure 27, 5-methoxy-quinolin-8-ylamine 586 (280 mg, 1.6 mmol), 2-nitro-4-(trifluoromethyl) benzenesulfonyl chloride (600 mg, 2.0 mmol), pyridine (0.39 ml, 4.8 mmol) DMAP (cat.) and DCM (15 ml) gave the title compound (500 mg, 73%) after purification by column chromatography with DCM as the eluent.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09102688B2 |
| Quelldatensatz | uspto-grants-2015_08 |
| ORD ID | ord-fb735ac125fa4316afcb78ba973106a8 |
| Quellennotiz | uspto-grants-2015_08 |