HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 2-Amino-N-(5-methoxy-quinolin-8-yl)-4-trifluoromethyl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | N-(5-Methoxy-quinolin-8-yl)-2-nitro-4-trifluoromethyl-benzenesulfonamide | HCID 68183320 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-N-(5-methoxy-quinolin-8-yl)-4-trifluoromethyl-benzenesulfonamide | HCID 68183365 | 94.6% |
Reaction Steps
In a similar fashion using route 2 general procedure 4 N-(5-methoxy-quinolin-8-yl)-2-nitro-4-trifluoromethyl-benzenesulfonamide 587 (500 mg, 1.17 mmol), SnCl2 (0.9 g, 4.6 mmol), 6N HCl (2 drops) and EtOH (10 ml) at 85° C. for 48 h gave the title compound (440 mg, 92%) which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-1eb25f39b6264b609616a70af4d0b586 |
| Source note | uspto-grants-2015_08 |