Ethanol → HCID 178432251, compound

HRID 513822Notes

Reaction equation

HRID 513822 reaction equation
[OH-].[Na+].C(O)C.[NH2:6][C:7]1[N:11]([C:12]2[CH:21]=[CH:20][C:15]3[NH:16][C:17]([CH3:19])=[N:18][C:14]=3[CH:13]=2)[N:10]=[CH:9][C:8]=1[C:22]([C:24]1[N:25](S(C2C=CC=CC=2)(=O)=O)[C:26]2[C:31]([CH:32]=1)=[CH:30][CH:29]=[CH:28][CH:27]=2)=[O:23]>O>[NH2:6][C:7]1[N:11]([C:12]2[CH:21]=[CH:20][C:15]3[NH:16][C:17]([CH3:19])=[N:18][C:14]=3[CH:13]=2)[N:10]=[CH:9][C:8]=1[C:22]([C:24]1[NH:25][C:26]2[C:31]([CH:32]=1)=[CH:30][CH:29]=[CH:28][CH:27]=2)=[O:23]

Participants

5

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 178432250HCID 178432250, compound

Product 1

HCID 178432251HCID 178432251, compoundYield 64.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

An aqueous solution (1.67 ml) of 4 M sodium hydroxide was added to an ethanol solution (17 ml) of [5-amino-1-(2-methyl-1H-benzimidazol-5-yl)-1H-pyrazol-4-yl]-(1-benzenesulfonyl-1H-indol-2-yl) methanone (87 mg). The resulting mixture was stirred at room temperature for 2 hours. The reaction mixture was poured into water. The resulting solid was collected by filtration, washed with water, and dried to give [5-amino-1-(2-methyl-1H-benzimidazol-5-yl)-1H-pyrazol-4-yl]-(1H-indol-2-yl) methanone (40 mg, 63%).

Workup

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-54ee2ab2f54e4dde8e84a9181f25e7b0
Source dataset
uspto-grants-2015_08
Patent number
US09102692B2

Reaction notes

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