HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 513929Generated: November 1, 2026
7-methoxy-2-methylquinoline-3-carboxylic acid → 3-Quinolinecarboxylicacid,7-hydroxy-2-methyl-(6CI)
https://huagongshe.com/reaction/513929
Participants
| Role | Name | HCID | Charge |
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| Reactant | 7-methoxy-2-methylquinoline-3-carboxylic acid | HCID 818248 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | 3-Quinolinecarboxylicacid,7-hydroxy-2-methyl-(6CI) | HCID 136219628 | 92% |
Reaction Steps
7-Methoxy-2-methylquinoline-3-carboxylic acid (100 mg, 0.46 mmol) was suspended in HBr (aq.) (48%, 5 ml) and heated at 105° C. overnight. The reaction was cooled to ambient temperature. The precipitate was collected by filtration and dried under high vacuum to afford the title compound as a yellow solid (86 mg, 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09102674B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-157e2b3f7f23468c913575dee1a43413 |
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| Source note | uspto-grants-2015_08 |
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