Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 3-Quinolinecarboxylicacid,7-hydroxy-2-methyl-(6CI) | HCID 136219628 | — |
| Product | HCID 136502002 | HCID 136502002 | — |
Reaction Steps
7-Hydroxy-2-methylquinoline-3-carboxylic acid (860 mg, 4.24 mmol) was dissolved in EtOH (29 mL) and H2SO4 (0.3 mL) was added. The reaction was heated at 75° C. for 23 h before being concentrated onto silica. Purification (FCC, SiO2, 0-5%, MeOH/DCM) afforded the title compound as a yellow solid sulfate salt (1.128 g, 81%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09102674B2 |
|---|
| Source dataset | uspto-grants-2015_08 |
|---|
| ORD ID | ord-716d9be2f2f744e19f4a760850c05b67 |
|---|
| Source note | uspto-grants-2015_08 |
|---|
