Acetone → HCID 67526913, compound

HRID 513978Notes

Reaction equation

HRID 513978 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[CH2:5][C:6]#[N:7].[CH3:12][C:13]([CH3:15])=O.[OH-].[K+]>CO>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5](=[C:13]([CH3:15])[CH3:12])[C:6]#[N:7]

Participants

5

Reactant 3

HCID 180AcetoneHCID 14797Potassium HydroxideHCID 81496(2-Methoxyphenyl)acetonitrile

Product 1

HCID 67526913HCID 67526913, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

According to the procedure described by Example 1, o-methoxybenzylcyanide (18.6 g, 127 mmol) is condensed with acetone (50 ml) under addition of methanol (6.5 ml) and KOH (3.33 g, 50 mmol) to yield, after workup and distillation at 106-110° C./0.05 mbar, 2-(2-methoxyphenyl)-3-methyl-but-2-ene nitrile (1.7 g, 7%).

Workup

  1. customto yield
  2. distillationafter workup and distillation at 106-110° C./0.05 mbar, 2-(2-methoxyphenyl)-3-methyl-but-2-ene nitrile (1.7 g, 7%)

Sources & evidence

ORD record
ord-5917829d1eac4bbb85011c3e763e7d12
Source dataset
uspto-grants-2015_08
Patent number
US09102899B2

Reaction notes

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