Acetone → HCID 67527184, compound

HRID 513979Notes

Reaction equation

HRID 513979 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([CH2:7][C:8]#[N:9])=[CH:5][CH:4]=1.[CH3:12][C:13]([CH3:15])=O.[OH-].[K+]>CO>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](=[C:13]([CH3:15])[CH3:12])[C:8]#[N:9])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 180AcetoneHCID 14797Potassium HydroxideHCID 66031Benzeneacetonitrile, 4-methoxy-

Product 1

HCID 67527184HCID 67527184, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

According to the procedure described by Example 1, p-methoxybenzylcyanide (18.6 g, 127 mmol) is condensed with acetone (50 ml) under addition of methanol (6.5 ml) and KOH (3.33 g, 50 mmol) to yield, after workup and distillation at 111-113° C./0.05 mbar, 2-(4-methoxyphenyl)-3-methyl-but-2-ene nitrile (14.3 g, 18%).

Workup

  1. customto yield
  2. distillationafter workup and distillation at 111-113° C./0.05 mbar, 2-(4-methoxyphenyl)-3-methyl-but-2-ene nitrile (14.3 g, 18%)

Sources & evidence

ORD record
ord-2db6201c14c54ce3a3b56fc698c0e267
Source dataset
uspto-grants-2015_08
Patent number
US09102899B2

Reaction notes

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