4-Methylcyclohexen-1-ylboronic acid → (2S)-2-tert-Butoxy-2-(3-methyl-1-(4-methylcyclohex-1-enyl)naphthalen-2-yl)acetic acid

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Reaction Steps

(2S)-2-tert-Butoxy-2-(3-methyl-1-(4-methylcyclohex-1-enyl)naphthalen-2-yl)acetic acid was prepared following the procedure to make (S)-2-tert-butoxy-2-(1-cyclohexenyl-3-methylnaphthalen-2-yl)acetic acid of Example 6, except that 4-methylcyclohex-1-enylboronic acid was used instead of cyclohexenylboronic acid. 1H-NMR: 400 MHz, (CD3OD) δ: 7.92-7.78 (m, 1H), 7.70 (m,1H), 7.52 (s, 1H), 7.39 (m, 2H), 6.10-5.58 (m, 2H), 2.56 (s,3H), 2.65-1.84 (m, 6H), 1.50 (m, 1H), 1.22 (s, 9H), 1.14 (t, 3H). LCMS-ESF (m/z): [M−H]− calcd for C24H29O3: 365.49. found: 365.1.

Provenance & Evidence