Trifluoroacetic acid → HCID 67126136, compound

Participants

Reaction Steps

To a solution of [1-(4-chloro-phenyl)-5-methoxy-3-methyl-naphthalen-2-yl]-(4-methoxy-benzyloxy)-acetic acid ethyl ester (58 mg, 0.115 mmol) in dichloromethane (3 mL) was added trifluoroacetic acid (58 μL). The reaction mixture was stirred for 2 h at room temperature and then quenched carefully with sat. NaHCO3. The aqueous layer was extracted with dichloromethane twice, and then the combined organic layers were washed with water, dried (Na2SO4), concentrated and purified by flash column chromatography to give desired (23 mg).

Provenance & Evidence