HCID 67126073, compound → HCID 56602524, compound

Participants

Reaction Steps

2-tert-Butoxy-2-(1-(4-chlorophenyl)-6-fluoro-3-methylnaphthalen-2-yl)acetic acid (42) was prepared similarly to 2-(5-bromo-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-tert-butoxyacetic acid of Example 35, using 6-fluoro-3-methyl-3,4-dihydronaphthalen-1(2H)-one instead of 5-bromo-3-methyl-3,4-dihydronaphthalen-1(2H)-one. 1H-NMR: 400 MHz, (CD3OD) δ: 7.67 (s, 1H), 7.57 (s, 2H), 7.55 (as, 1H), 7.45 (dd, J=9.8, 2.8 Hz, 1H), 7.32 (d, J=8.4 Hz, 1H), 7.27 (dd, J=9.4, 5.2 Hz, 1H), 7.11 (td, J=9.0, 2.4 Hz, 1H) 5.16 (s, 1H), 2.60 (s, 3H), 0.98 (s, 9H). 19F-NMR: 377 MHz, (CD3OD) δ: −118.01 (s). LCMS-ESI− (m/z): [M—H]− calcd for C23H21ClFO3: 399.12; found: 399.19.

Provenance & Evidence