Lithium Hydroxide → HCID 56599322, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 2-tert-butoxy-2-(1-(4-chlorophenyl)-6-methoxy-3-methylnaphthalen-2-yl)acetate (16.2 mg, 0.037 mmol) in tetrahydrofuran:ethanol:water (2:2:1, 2.5 mL) was added lithium hydroxide (4 mg, 0.183 mmol) and the reaction was heated at 50° C. overnight. The reaction was purified by reverse phase HPLC (Gemini, 20-90% ACN/H2O+0.1% TFA) to give a white powder (12 mg). 1H-NMR: 400 MHz, (CD3OD) δ: 7.60 (s, 1H), 7.55 (m, 3H), 7.30 (m, 1H), 7.17 (d, J=2.8 Hz, 1H), 7.13 (d, J=9.6 Hz, 1H), 6.94 (dd, J=9.2, 2.8 Hz, 1H), 5.15 (s, 1H), 3.90 (s, 3H), 2.58 (s, 3H), 0.98 (s, 9H). LCMS-ESI− (m/z): [M−H]− calcd for C24H24ClO4: 411.14; found: 411.14.

Provenance & Evidence