(Pyridin-4-yl)boronic acid → (S)-2-tert-butoxy-2-(1-(4-chlorophenyl)-3-methyl-6-(pyridin-3-yl)naphthalen-2-yl)acetic acid

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Reaction Steps

(S)-2-tert-butoxy-2-(1-(4-chlorophenyl)-3-methyl-6-(pyridin-3-yl)naphthalen-2-yl)acetic acid (54) was prepared in a similar fashion to compound 53 of Example 51 with the substitution of pyridin-3-ylboronic acid for pyridin-4-ylboronic acid in step 5. The title compound (0.024 g) was isolated as an amorphous white powder. LCMS-ESI− (m/z): [2M−H]− calcd for C56H51Cl2N2O6: 917.31; found: 917.39. 1H-NMR: 400 MHz, (CD3CN) δ: 9.08 (s, 1H); 8.74 (d, J=5.2 Hz, 1H); 8.61 (d, J=8 Hz, 1H); 8.19 (s, 1H); 7.93-7.88 (m, 1H); 7.84 (s, 1H); 7.66-7.53 (m, 4H); 7.44-7.35 (m, 2H); 5.24 (s, 1H); 2.59 (s, 3H); 0.99 (s, 9H).

Provenance & Evidence