HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethynylcyclohexanol → HCID 67126155, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethynylcyclohexanol | HCID 6525 | — |
| Reactant | Ethyl 2-(7-bromo-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-tert-butoxyacetate | HCID 67126201 | — |
| Solvent | Acetonitrile--water (1/1) | HCID 18373917 | — |
| Product | HCID 67126155 | HCID 67126155 | — |
Reaction Steps
2-tert-Butoxy-2-(1-(4-chlorophenyl)-7-((1-hydroxycyclohexyl)ethynyl)-3-methylnaphthalen-2-yl)acetic acid (83) was prepared by the method of Example 67 from ethyl 2-(7-bromo-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-tert-butoxyacetate using 1-ethynylcyclohexanol. 1H-NMR: 400 MHz, (CD3OD) δ: 7.75 (d, J=8 Hz, 1H), 7.68 (s, 1H), 7.58 (m, 3H), 7.40 (d, J=8 Hz, 1H), 7.31 (d, J=8 Hz, 1H), 7.28 (s, 1H), 5.17 (s, 1H), 2.60 (s, 3H), 1.91 (m, 2H), 1.57-1.71 (m, 8H), 0.98 (s, 9H). HPLC (Kinetex 2.6u, 50×4.6 mm, 2-100% MeCN/H2O+0.05% HOAc, 3.5 min run): tR (min)=2.66.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102614B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-b6d5a37ae14a408589eb8b3b18776f23 |
| Source note | uspto-grants-2015_08 |