HCID 86691556, compound → HCID 86691555, compound

HRID 514106Notes

Reaction equation

HRID 514106 reaction equation
[C:1]([O:5][C@@H:6]([C:12]1[C:21]([CH3:22])=[CH:20][C:19]2[C:14](=[CH:15][C:16]([F:25])=[C:17]([CH:23]=[CH2:24])[CH:18]=2)[C:13]=1[O:26][S:27]([C:30]([F:33])([F:32])[F:31])(=[O:29])=[O:28])[C:7]([O:9][CH2:10][CH3:11])=[O:8])([CH3:4])([CH3:3])[CH3:2]>[Pd].C(O)C>[C:1]([O:5][C@@H:6]([C:12]1[C:21]([CH3:22])=[CH:20][C:19]2[C:14](=[CH:15][C:16]([F:25])=[C:17]([CH2:23][CH3:24])[CH:18]=2)[C:13]=1[O:26][S:27]([C:30]([F:32])([F:33])[F:31])(=[O:29])=[O:28])[C:7]([O:9][CH2:10][CH3:11])=[O:8])([CH3:3])([CH3:4])[CH3:2]

Participants

4

Reactant 1

HCID 86691556HCID 86691556, compound

Product 1

HCID 86691555HCID 86691555, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of (S)-ethyl 2-tert-butoxy-2-(7-fluoro-3-methyl-1-(trifluoromethylsulfonyloxy)-6-vinylnaphthalen-2-yl)acetate (23 mg, 0.050 mmol) and 10% Palladium on carbon (5 mg) in ethanol (2.0 mL) was stirred under a hydrogen atmosphere for 4 hours, then filtered through a pad of Celite. Filtrate was concentrated to give a thin film (23 mg) that was used in the next step without further purification.

Workup

  1. filtrationfiltered through a pad of Celite
  2. concentrationFiltrate was concentrated
  3. customto give a thin film (23 mg) that
  4. customwas used in the next step without further purification

Sources & evidence

ORD record
ord-96c7ecd3f4744b30a21d9d9c50a4a740
Source dataset
uspto-grants-2015_08
Patent number
US09102614B2

Reaction notes

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