3-Methyl-1,2,3,4-tetrahydronaphthalen-1-one → Ethyl 2-(4-methoxybenzyloxy)-2-(1-hydroxy-3-methylnaphthalen-2-yl)acetate

Participants

Reaction Steps

Ethyl 2-(4-methoxybenzyloxy)-2-(1-hydroxy-3-methylnaphthalen-2-yl)acetate was prepared in a similar manner as (1-hydroxy-5-methoxy-3-methyl-naphthalen-2-yl)-(4-methoxy-benzyloxy)-acetic acid ethyl ester of Example 32, except using 3-methyl-3,4-dihydronaphthalen-1(2H)-one. 1H NMR (400 MHz, CDCl3) δ 8.51 (s, 1H), 8.24 (d, J=8.2 Hz, 1H), 7.65 (d, J=7.8 Hz, 1H), 7.48-7.36 (m, 2H), 7.27 (d, 8.5 Hz, 2H), 7.18 (s, 1H), 6.89 (d, J=8.4 Hz, 2H), 5.30 (s, 1H), 4.67-4.55 (m, 2H), 4.27-4.08 (m, 2H), 3.82 (s, 3H), 2.40 (s, 3H), 1.19 (t, J=7.0 Hz, 3H).

Provenance & Evidence