Phenylboronic Acid → 2-Tert-butoxy-2-(1-(4-chlorophenyl)-3-methyl-4-phenylnaphthalen-2-yl)acetic acid

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Reaction Steps

2-tert-Butoxy-2-(1-(4-chlorophenyl)-3-methyl-4-phenylnaphthalen-2-yl)acetic acid (136) was prepared in a manner similar to 2-tert-butoxy-2-(1-(4-chlorophenyl)-3,4-dimethylnaphthalen-2-yl)acetic acid of Example 125, except using benzeneboronic acid in the Suzuki reaction, giving the title compound (parent form). 1H-NMR: (400 MHz, MeOH-d4): δ 7.67-7.55 (m, 5H); 7.50-7.48 (m, 1H); 7.41-7.39 (m, 1H); 7.33-7.23 (m, 6H); 5.31 (s, 1H); 2.28 (s, 3H); 1.02 (s, 9H). LCMS-ESI− (m/z): [M−H]− calcd for C29H26ClO3: 457.2; Found: 457.2.

Provenance & Evidence