Ethyl 2-(7-chloro-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-hydroxyacetate → Ethyl 2-tert-butoxy-2-(7-chloro-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)acetate

HRID 514155Notes

Reaction equation

HRID 514155 reaction equation
[C:1](O[C@@H](C1C(C)=CC2C(=CC=C(OS(C(F)(F)F)(=O)=O)C=2)C=1C1C=CC(Cl)=CC=1)C(OCC)=O)([CH3:4])([CH3:3])[CH3:2].[Cl:38][C:39]1[CH:48]=[C:47]2[C:42]([CH:43]=[C:44]([CH3:63])[C:45]([CH:56]([OH:62])[C:57]([O:59][CH2:60][CH3:61])=[O:58])=[C:46]2[C:49]2[CH:54]=[CH:53][C:52]([Cl:55])=[CH:51][CH:50]=2)=[CH:41][CH:40]=1>>[C:1]([O:62][CH:56]([C:45]1[C:44]([CH3:63])=[CH:43][C:42]2[C:47](=[CH:48][C:39]([Cl:38])=[CH:40][CH:41]=2)[C:46]=1[C:49]1[CH:50]=[CH:51][C:52]([Cl:55])=[CH:53][CH:54]=1)[C:57]([O:59][CH2:60][CH3:61])=[O:58])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 67126265Ethyl 2-(7-chloro-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-hydroxyacetateHCID 86691548(S)-ethyl 2-tert-butoxy-2-(1-(4-chlorophenyl)-3-methyl-6-(trifluoromethylsulfonyloxy)naphthalen-2-yl)acetate

Product 1

HCID 67126236Ethyl 2-tert-butoxy-2-(7-chloro-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)acetate

Procedure

Ethyl 2-tert-butoxy-2-(7-chloro-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)acetate was prepared in a manner similar to (S)-ethyl 2-tert-butoxy-2-(1-(4-chlorophenyl)-3-methyl-6-(trifluoromethylsulfonyl-oxy)naphthalen-2-yl)acetate of Example 51, except using racemic ethyl 2-(7-chloro-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-hydroxyacetate. Material was carried on crude without further characterization.

Sources & evidence

ORD record
ord-51fdf7396f444e169119de725aea1437
Source dataset
uspto-grants-2015_08
Patent number
US09102614B2

Reaction notes

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