反应详情

温度

27.5 °C

To a solution of 2-(4-bromo-2,6-dimethylphenyl)-3-methoxy-5-[1-pyridin-2-ylmethylidene]cyclopent-2-enone (2.8 g, 7.3 mmol) in acetic acid (30 ml) is added zinc powder (2.3 g, 36.5 mmol) at 25-30°C. The resulting suspension is stirred at 25-30°C. for 6-7 hours, then filtered through a bed of diatomaceous earth and washed with methanol (20 ml×2). The filtrate is concentrated under vacuum, water is added and the crude product is extracted with ethyl acetate (50 ml×3). The combined organic fractions are washed with distilled water, brine, dried over sodium sulfate, filtered and the filtrate concentrated in vacuo. The crude is purified by flash column chromatography to afford rac-2-(4-bromo-2,6-dimethylphenyl)-3-methoxy-5-pyridin-2-ylmethylcyclopent-2-enone.

1. filtrationfiltered through a bed of diatomaceous earth
2. washwashed with methanol (20 ml×2)
3. concentrationThe filtrate is concentrated under vacuum, water
4. additionis added
5. extractionthe crude product is extracted with ethyl acetate (50 ml×3)
6. washThe combined organic fractions are washed with distilled water, brine
7. dry with materialdried over sodium sulfate
8. filtrationfiltered
9. concentrationthe filtrate concentrated in vacuo
10. customThe crude is purified by flash column chromatography