Hydrochloric Acid → HCID 71566787, compound

Participants

Reaction Conditions

Reaction Steps

Aqueous 2M hydrochloric acid (1.20 ml) is added to a solution of rac-2-(4-chloroethynyl-2,6-dimethylphenyl)-3-methoxy-5-pyridin-2-ylmethylcyclopent-2-enone (0.120 g, 0.33 mmol) in acetone (1.20 ml), and the reaction mixture is heated at 60°C. for 2 hours. The solution is then concentrated in vacuo, and the crude product is purified by preparative reverse phase HPLC to afford rac-2-(4-chloroethynyl-2,6-dimethylphenyl)-4-pyridin-2-ylmethylcyclopentane-1,3-dione.

Provenance & Evidence