Methylamine → HCID 89600830, compound

Participants

Reaction Steps

To 6-[[3-(4-bromo-2,6-dimethyl-phenyl)-4-methoxy-2-oxo-cyclopent-3-en-1-yl]methyl]-2-methylsulfonyl-pyridine-3-carbonitrile (2.043 mmol, 1 g) was added a solution of methylamine (5.1 ml of a 2M solution in tetrahydrofuran, 10.22 mmol). The reaction was stirred at room temperature for three hours and then concentrated under reduced pressure to give a brown gum. The crude product was purified by column chromatography on SiO2 using a hexane: EtOAc gradient to yield the desired compound (890 mg, 99%) as an orange solid. 1H NMR (400 MHz, CDCl3) (diagnostic peaks) δ ppm 7.55 (d, 1H), 7.18 (d, 2H), 6.45 (d, 1H), 3.55 (s, 3H), 3.05 (d, 3H), 2.15 (s, 3H), 2.00 (s, 3H).

Provenance & Evidence