反应详情

温度

-10 °C

Ethyl 6-chloro-1-ethyl-2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1H-indole-5-carboxylate (0.10 g, 0.19 mmol) was dissolved in 5 ml of dichloromethane and a solution of boron tribromide in dichloromethane (0.96 ml, 0.96 mmol) was added dropwise at −10° C. The reaction mixture was stirred at −10° C. for 1 h and then at room temperature for 2 h. Water was added and the precipitated solid was filtered off with suction and dried. 0.077 g (71% of theory) of 6-chloro-1-ethyl-2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1H-indole-5-carboxylic acid was obtained.

1. waitat room temperature for 2 h
2. filtrationthe precipitated solid was filtered off with suction
3. customdried