Trifluoroacetic acid → HCID 86713977, compound

Participants

Reaction Steps

tert-Butyl {[6-chloro-1-ethyl-2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1H-indol-5-yl]methyl}carbamate (0.42 g, 0.72 mmol) was dissolved in dichloromethane (5 ml), and trifluoroacetic acid (0.82 g, 7.18 mmol) was added. The reaction mixture was stirred at room temperature for 2 h and then the solvent was removed under reduced pressure. 0.42 g (97% of theory) of [6-chloro-1-ethyl-2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1H-indol-5-yl]methanaminium trifluoroacetate was obtained.

Provenance & Evidence