Acetic Anhydride → HCID 86713979, compound

Participants

Reaction Steps

At 0° C., [6-chloro-1-ethyl-2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1H-indol-5-yl]methanaminium trifluoroacetate (0.07 g, 0.15 mmol), triethylamine (0.036 g, 0.36 mmol) and N,N-dimethylpyridin-4-amine (0.002 g, 0.12 mmol) were initially charged in dichloromethane (1 ml). Acetic anhydride (0.021 g, 0.21 mmol) was added dropwise and the reaction mixture was stirred at room temperature for 16 h. Ethyl acetate was added and the organic phase was washed successively with water, saturated ammonium chloride solution and saturated sodium hydrogencarbonate solution. The organic phase was dried over sodium sulphate and the solvent was removed under reduced pressure. 0.06 g (98% of theory) of 5-(acetamidomethyl)-6-chloro-1-ethyl-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}-1H-indole-2-carboxamide was obtained.

Provenance & Evidence