Methyl 2,2,2-trichloroacetimidate → HCID 68292772, compound

Participants

Reaction Steps

To a solution of 4,5-diamino-2-chloro-N-cyclopropylbenzamide (4.1 g, 18.2 mmol) in glacial acetic acid (50 ml) was added, at 0° C., methyl 2,2,2-trichloroacetimidate (2.21 ml, 18.2 mmol). The reaction mixture was stirred at room temperature for 16 h and then the solvent was removed under reduced pressure. The 6-chloro-N-cyclopropyl-2-(trichloromethyl)-1H-benzimidazole-5-carboxamide was used for Stage 4 directly without purification.

Provenance & Evidence